NEWSWIRETODAY Press Release& Newswire Distribution | HOME
PRTODAY / NewswireToday press release distribution service network
Agency / Source: The Scott Partnership

Check Ads Availability|e-mail Article

Are you the owner of this article?, Turn it PREMIUM with your LOGO instead - and make it 3rd party Ads-Free! within the next hour!

Optibrium Announces Models to Predict Toxicity of Compounds - Optibrium announces models to predict toxicity of compounds. Stardrop’s glowing molecule provides visual link between chemical structure and predicted toxicities -
Optibrium Announces Models to Predict Toxicity of Compounds


NewswireTODAY - /newswire/ - Cambridge, United Kingdom, 2011/05/25 - Optibrium announces models to predict toxicity of compounds. Stardrop’s glowing molecule provides visual link between chemical structure and predicted toxicities -

Your Banner Ad Here instead - Showing along with ALL Articles covering Medical Services / Equipment Announcements

Replace these Affiliate Programs at ANYTIME! Your banner here within the next hour. Learn How!


Optibrium, a provider of software solutions for drug discovery, announces the availability of a range of models to help predict the toxicity of potential new compounds. Optibrium has generated a range of Quantitative Structure Activity Relationship (QSAR) models of key toxicity endpoints, based on data made available by the US Environmental Protection Agency (EPA) as part of its Toxicity Evaluation Software Toolkit (T.E.S.T.). The toxicity prediction models were built with the Auto-Modeller module of the newly launched StarDrop 5 and are available to all StarDrop users free-of-charge. To find out more and download the models please visit Optibrium’s on-line community at

Whether compounds are intended as drugs, cosmetics, agrochemicals or for other industrial applications, it is essential to understand their potential to cause toxic effects. Understanding this can allow scientists to prioritise chemical structures for further research or identify the most appropriate downstream experiments to confirm their safety. However, the ability to predict toxicities in compounds can be extremely challenging.

Models have a high degree of uncertainty in the predictions they make due to the complexity and variety of chemical and biological mechanisms that lead to toxicities.

StarDrop, from Optibrium, is an interactive platform that guides scientists to make decisions on the design and selection of high quality compounds with the aim of achieving an optimal balance of properties. StarDrop provides an ideal environment for application of toxicity models to the selection of compounds. Its probabilistic scoring algorithm allows predictive models of toxicity to be used, while explicitly taking into consideration the uncertainty in each prediction. This ensures that uncertain predictions are not given undue weight, relative to other data, when prioritising compounds that are more likely to have an appropriate balance of properties. As a result, compounds which are more likely to be toxic are efficiently identified, improving lead optimisation. The unique Glowing Molecule feature within StarDrop offers an innovative visualisation that highlights regions of a compound with a significant influence on a predicted property. As a result, this provides a link between the predicted toxicity and the chemical mechanism and guides users in the redesign of compounds with improved safety.

“These predictive toxicity models complement the range of properties that can already be predicted with StarDrop’s ADME QSAR module. As they’re based on public-domain data sets, we’re pleased to offer them free-of-charge to all of our users.” comments Dr. Matthew Segall, CEO of Optibrium. “Many of the toxicity prediction models developed with the use of StarDrop are particularly relevant to potential environmental pollutants. This illustrates the usability of StarDrop not just for drug discovery applications, but for industrial, agrochemical or cosmetic applications.”

The toxicity prediction models conform to the Organisation for Economic Cooperation and Development (OECD) principles for validation of QSAR models for regulatory purposes and have also been found to perform equivalently or better than the EPA T.E.S.T. models on the same validation sets. All models were built automatically with StarDrop’s Auto-modeller module, illustrating that the Auto-Modeller is capable of building models that compare favourably with those created with more ‘manual’ methods. For further information please visit Optibrium’s on-line community at

About Optibrium Ltd
Optibrium ( is dedicated to providing software to guide decisions involving complex, uncertain data in an intuitive way. Based in Cambridge, UK, Optibrium has a global customer base ranging from top-ten pharmaceutical companies to small biotechs and academic groups. Our mission is to continue to develop new technologies that will optimise project strategy, reduce wasted molecules and experiments, shorten timelines and improve the quality of candidate compounds for our clients. Optibrium’s primary product, StarDrop, is focused on the drug discovery industry, helping guide scientists to make decisions in the design and selection of high quality drug candidates. Visit the online community for further discussions on improving the productivity of drug discovery.

Your Banner Ad Here instead - Showing along with ALL Articles covering Medical Services / Equipment Announcements

Replace these Affiliate Programs at ANYTIME! Your banner here within the next hour. Learn How!


Agency / Source: The Scott Partnership


Availability: All Regions (Including Int'l)


Traffic Booster: [/] Quick NewswireToday Visibility Checker


Distribution / Indexing: [+]

# # #
  Your Banner Ad showing on ALL
Medical Services / Equipment articles,
CATCH Visitors via Your Competitors Announcements!

Optibrium Announces Models to Predict Toxicity of Compounds

Company website links NOT available to basic submissions
It is OK to republish and/or LINK any newswire for any legitimate media purpose as long as you name NewswireToday and LINK as the source.
  For more information, please visit:
Is this your article? Activate ALL web links by Upgrading to Press Release PREMIUM Plan Now!
Contact: Sarah Evans - 
+44(0)14 7753 9539 optibrium[.]
PRZOOM / PRTODAY - Newswire Today disclaims any content contained in this article. If you need/wish to contact the company who published the current release, you will need to contact them - NOT us. Issuers of articles are solely responsible for the accuracy of their content. Our complete disclaimer appears here.
IMPORTANT INFORMATION: Issuance, publication or distribution of this press release in certain jurisdictions could be subject to restrictions. The recipient of this press release is responsible for using this press release and the information herein in accordance with the applicable rules and regulations in the particular jurisdiction. This press release does not constitute an offer or an offering to acquire or subscribe for any The Scott Partnership securities in any jurisdiction including any other companies listed or named in this release.

Medical Services / Equipment via RSSAdd NewswireToday - PRZOOM Headline News to FeedBurner
Find who RetweetFollow @NewswireTODAY

Are you the owner of this article?, Turn it PREMIUM with your LOGO instead - and make it 3rd party Ads-Free! within the next hour!

Read Latest Articles From The Scott Partnership / Company Profile

Read Medical Services / Equipment Most Recent Related Newswires:

SCHOTT Pharma Launches Large Format Ready-to-Use Cartridges for On-body Devices
Nexans Invests in its Draveil Site to Double Production Capacity of Medical Cables
SCHOTT Pharma and KORU Medical Systems Announce Collaboration to Advance Large Volume Subcutaneous Infusion
Tongue-operated AI-powered Device that Aims to Challenge Neuralink, Wins Red Dot 2024 Award
Bruker Applied Mass Spectrometry Division Showcases High-Performance Solutions for Research and Analysis in Applied Laboratories
Bruker Launches Ultimate Sensitivity timsTOF Ultra 2 to Enable New Research Paradigms in Single-Cell and Subcellular Proteomics
Cancer Treatment Using Rotating Gantry of the Toshiba Heavy Ion Therapy System Starts At Yonsei University Health System
Bruker's Canopy Biosciences Announces the Launch of CellScape™ Whole-Slide Imaging Chamber for Spatial Biology
iSono Health Applauded by Frost & Sullivan for Ensuring Patient Comfort and Safety Providing Quality Imaging & Diagnosis with its iSono Health ATUSA
Bruker Launches the New BEAM, a Dedicated Single-Point FT-NIR Spectrometer Designed for In-Process Control
Bruker Introduces the Ingenious Novel ‘Triceratops’ SPR #64 Surface Plasmon Resonance System for Drug Discovery At SLAS2024
Yokogawa Introduces CellVoyager High-Content Analysis System CQ3000
Advantech Introduces Cutting-Edge Solutions to Address Diverse Imaging Needs in Operating Rooms - The AVAS-2 Series for 4K Streaming Excellence
Seno Medical Earns Frost & Sullivan’s 2023 United States Enabling Technology Leadership Award for Delivering a More Efficient Breast Cancer Diagnosis
Withings Announces BeamO The Revolutionary At-home Health Checkup

Boost Your Social Network
& Crowdfunding Campaigns

NewswireToday Celebrates 10 Years in Business



Visit  Limelon Advertising, Co.

  ©2005-2024 NewswireToday — Limelon Advertising, Co.
Home | About | Advertise/Pricing | Contact | Investors | Privacy/TOS | Sitemap | FRANCAIS
newswire, PR press releases distribution service magazines engine news alert newsroom press room breaking news public relations articles company news alerts newswiredistribution ezine bizentrepreneur biznewstoday digital business report market search pr firms agencies reports distri-bution today investor relation successful internet entrepreneurs newswire distribution newswiredistribution asianewstoday bizwiretoday USA pr UK today - NOT affiliated with PRNewswire as we declined their partnership offer in 2013
PRTODAY & NewswireTODAY are proudly NOT affiliated with USA TODAY (