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Written by / Agency / Source: Randox Laboratories Ltd
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Randox Introduces the Gold Standard in Renal Damage Testing – Cystatin C - The Predictive Safety Testing Consortium (PSTC) has provided data which supports the use of various renal markers, including Cystatin C, in a preclinical setting
Randox Introduces the Gold Standard in Renal Damage Testing – Cystatin C

 

NewswireToday - /newswire/ - Crumlin, Antrim, United Kingdom, 2010/07/14 - The Predictive Safety Testing Consortium (PSTC) has provided data which supports the use of various renal markers, including Cystatin C, in a preclinical setting.

   
 
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The biomarkers have been shown to outperform traditional markers, such as creatinine and blood urea nitrogen (BUN), in both specificity and sensitivity. Cystatin C and many other renal damage biomarkers are available from Randox Laboratories (randoxonlinestore.com).

Due to drug-induced toxicity being such a serious issue, it is vital that quality preclinical toxicity biomarkers are available to avoid such affected products being marketed and reaching the consumer. A recent report from the PSTC set out to discover what makes a good safety biomarker. They concluded; “first, the marker must be present in peripheral body tissue and/or fluid (e.g., blood, urine, saliva, breath or cerebrospinal fluid); second, it must be easy to detect or quantify in assays that are both affordable and robust; and third, its appearance must be associated as specifically as possible with damage of a particular tissue, preferably in a quantifiable manner.”

It was noted that the traditional renal damage markers; creatinine and BUN conform only to the first two of these three critical criteria. However it has now been accepted by regulators that the following biomarkers are superior in specificity and sensitivity:

• Cystatin C
• Albumin
• Total protein
• Β2-microglobulin

As further confirmation, the study stated; “Between June 2007 and January 2008, these data were presented to the authorities, which by April 2008 had accepted that these biomarkers outperformed the current standards.”

Randox Laboratories (randox.com) has nearly 30 years experience in providing the highest quality clinical diagnostic reagents for use in laboratories worldwide. All of the above mentioned biomarkers are included in our comprehensive portfolio, therefore enabling a reliable diagnosis of renal damage. Ensure your laboratory is using the gold standard and achieving results you can trust. Randox is at the cutting-edge of laboratory medicine, providing innovative technologies to cover all your testing needs.

 
 
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Written by / Agency / Source: Randox Laboratories Ltd

 
 

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Randox Introduces the Gold Standard in Renal Damage Testing – Cystatin C

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Publisher Contact: Charlotte Jess - Randox.com 
+44(0)28 9442 2413 marketing[.]randox.com
 
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