Ipsen today announced the presentation of 12 abstracts during the 11th World Congress for Neurorehabilitation (WCNR) (wcnr-congress.org), taking place virtually between 7-11 October 2020.1-13
Spasticity is a disabling condition in adults and children, characterized by velocity-dependent muscle hyperactivity. It is the consequence of many neurological diseases, such as stroke, multiple sclerosis (MS), Traumatic Brain and Spinal Cord Injury and Cerebral Palsy. Spasticity can have significant impact on the lives of patients, causing multi-level disability, including impaired walking and hand use, pain, disfigurement and contractures.14 Cervical dystonia is a rare disorder of unknown origin in most of the primary cases, characterized by involuntary contractions of the neck muscles.15
“Our goal at Ipsen is to put the patient at the center of everything we do; our research aims to understand and address the unmet needs and support care optimization by providing tailored therapeutic solutions that help patients regain more control of their lives,” said Dr. Andreas Lysandropoulos, Vice President Medical Affairs Neuroscience, Ipsen.
Overview of Ipsen presentations at the WCNR 2020 Congress:1-12
Abstract title - Poster number/Session timing (CEST)
• Differences in the patient experience of spasticity management with botulinum toxin type A: A comparison of European versus American survey findings - Poster number: P0274 / Session timing: 09.00-20.00 7/10/2020
• An international, multicentre, observational, longitudinal study to assess the effectiveness of abobotulinumtoxinA injections for adult lower limb spasticity: The AboLiSh study - Poster number: P0275 / Session timing: 09.00-20.00 7/10/2020
• Longitudinal goal attainment with integrated upper limb spasticity management including botulinum toxin A: Primary results from the ULIS-III study - Poster number: P0276 / Session timing: 09.00-20.00 7/10/2020
• Real-life data on the time to retreatment with botulinum toxin A in upper limb spasticity management - Poster number: P0278 / Session timing: 09.00-20.00 7/10/2020
• Perceptions of burden of spasticity and treatment satisfaction among post-stroke patients over the course of a botulinum neurotoxin A (BoNT-A) treatment cycle: an ethnographic study - Poster number: P0279 /
Session timing: 09.00-20.00 7/10/2020
• 7-Year Experience from the Ixcellence Network®: An International Innovative Educational Program To Improve Cervical Dystonia And Spastic Paresis Management - Poster number: P0301 / Session timing: 09.00-20.00 7/10/2020
• Importance of Training and Practice Regarding Rehabilitation Approaches Integrated with Botulinum Neurotoxin-A Guided Injection in Cervical Dystonia & Spastic Paresis: results from the INPUT survey - Poster number: P0302 / Session timing: 09.00-20.00 7/10/2020
• Efficacy and safety of abobotulinumtoxinA in pediatric lower limb spasticity: 2nd interim results from a phase IV, prospective, observational, multicenter study - Poster number: P0304 / Session timing: 09.00-20.00 7/10/2020
• Development of the Hygiene Extension Limb position Pain (HELP) Tool to monitor waning of clinical efficacy in patients with spasticity or cervical dystonia treated with botulinum toxins - Poster number: P0306 / Session timing: 09.00-20.00 7/10/2020
• Economic analysis of real-world use of BotulinumtoxinA products (BoNTA) for treatment of adult upper limb spasticity (AUL) - Poster number: P0311 / Session timing: 09.00-20.00 7/10/2020
• AbobotulinumtoxinA for upper limb spasticity in children with cerebral palsy: Efficacy and safety findings from an international, Phase 3, pivotal study - Poster number: P0503 / Session timing: 09.00-20.00 7/10/2020
• Neuromodulation of cortical beta oscillatory activity following botulinum injection in post-stroke. - Oral presentation number: OP068 / Session timing: 9.45 11/10/2020
Spasticity is estimated to affect more than 12 million people worldwide.16 It is a condition in which certain muscles are continuously contracted causing stiffness or tightness of the muscles, which can interfere with normal movement, gait and speech.17 Spasticity is usually caused by damage to the parts of the brain or spinal cord that control voluntary movement, 17-18 leading to a change in the balance of signals between the nervous system and the muscles which leads to increased activity in the muscles.17 Spinal cord injury, multiple sclerosis, cerebral palsy, stroke, brain or head trauma and metabolic diseases can all cause spasticity.18 Spasticity is experienced by approximately 34% of stroke survivors within 18 months following a stroke.19
About cervical dystonia
Cervical dystonia (CD), also known as spasmodic torticollis, is a movement disorder in which involuntary muscular contractions occur primarily in the neck muscles.15,20 This can cause the head to turn to one side or to be pulled backward or forward.15,21 CD is relatively uncommon, affecting 57 to 280 people per million.22 It can occur at any age, although symptoms generally appear in middle age, often beginning slowly and usually reaching a plateau over a few months or years.23 The degeneration of the spine, irritation of nerve roots or frequent headaches can make CD particularly painful.23 In most cases the cause is unknown and no cure exists.22
Dysport® (abobotulinumtoxinA) is an injectable form of a botulinum neurotoxin type A (BoNT-A) product, which is a substance derived from Clostridium bacteria producing BoNT-A that inhibits the effective transmission of nerve impulses and thereby reduces muscular contractions. It is supplied as a lyophilized powder. AbobotulinumtoxinA has marketing authorization in more than 85 countries and more than 30 years of clinical experience.
The detailed recommendations for the use of Dysport are described in the Summary of Product Characteristics (SmPC) for Dysport (300 units) Powder and Dysport (500 units) Powder, and the U.S. Prescribing Information (PI).
NOTE: Dysport® labels and approved indications may vary from country to country.
Ipsen (ipsen.com) is a global specialty-driven biopharmaceutical group focused on innovation and Specialty Care. The Group develops and commercializes innovative medicines in three key therapeutic areas Oncology, Neuroscience, and Rare Diseases. Ipsen also has a well-established Consumer Healthcare business. With total sales over €2.5 billion in 2019, Ipsen sells more than 20 drugs in over 115 countries, with a direct commercial presence in more than 30 countries. Ipsen’s R&D is focused on its innovative and differentiated technological platforms located in the heart of the leading biotechnological and life sciences hubs (Paris-Saclay, France; Oxford, UK; Cambridge, US). The Group has about 5,800 employees worldwide.
Ipsen’s Forward Looking Statement
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1. Jacinto et al., WCNR 2020. Differences in the patient experience of spasticity management with botulinum toxin type A a comparison of European versus American survey findings.
2. Esquenazi et al., WCNR 2020. An international, multicentre, observational, longitudinal study to assess the effectiveness of abobotulinum toxin A injections for adult lower limb spasticity The AboLiSh study.
3. Turner-Stokes et al., WCNR 2020. Longitudinal goal attainment with integrated upper limb spasticity management including botulinum toxin A Primary results from the ULIS-III study.
4. Jacinto et al., WCNR 2020. Real-life data on the time to retreatment with botulinum toxin A in upper limb spasticity management.
5. Jacinto et al., WCNR 2020. Perceptions of burden of spasticity and treatment satisfaction among post-stroke patients over the course of a botulinum neurotoxin A (BoNT-A) treatment cycle an ethnographic study.
6. Dursun et al., WCNR 2020. 7-year experience from the Ixcellence Network® an international innovative educational program to improve cervical dystonia and spastic paresis management.
7. Jacinto et al., WCNR 2020. Importance of training and practice regarding rehabilitation approaches integrated with botulinum neurotoxin-A guided injection in cervical dystonia & spastic paresis results from the INPUT survey.
8. Gormley et al., WCNR 2020. Efficacy and safety of abobotulinum toxin A in pediatric lower limb spasticity 2nd interim results from a phase IV, prospective, observational, multicenter study.
9. Patel et al., WCNR 2020. Development of the Hygiene Extension Limb position Pain (HELP) tool to monitor waning of clinical efficacy in patients with spasticity or cervical dystonia treated with botulinum toxins.
10. Schnitzler et al., WCNR 2020. Economic analysis of real-world use of Botulinum toxin A products (BoNTA) for treatment of adult upper limb spasticity (AUL).
11. Dabrowski, et al., WCNR 2020. Efficacy and safety of abobotulinum toxin A for upper limb spasticity in children with cerebral palsy.
12. Chalard et al., WCNR 2020. Neuromodulation of cortical beta oscillatory activity following botulinum injection in post-stroke.
13. WCNR Virtual Congress 2020: Abstracts. WCNR. Accessed: October 2020.
14. Royal College of Physicians, British Society of Rehabilitation,“Spasticity in adults: management using botulinum toxin. National Guidelines”; 2018
15. Mayo Clinic. Cervical Dystonia.
16. John Hopkins Medicine. Spasticity.
17. American Association of Neurological Surgeons. Spasticity.
18. American Association of Neurological Surgeons. Movement Disorders.
19. Kuo C. Post-stroke Spasticity: A review of epidemiology, pathophysiology, and treatments. Int J Gerontol 2018;12:280-284.
20. Claypool D, et al. Epidemiology and outcome of cervical dystonia (spasmodic torticollis) in Rochester, Minnesota. Movement Disorders 1995;10: 608-614.
21. National Institute of Neurological Disorders and Stroke. Dystonias Fact Sheet.
22. Castelão M, et al. Botulinum toxin type A therapy for cervical dystonia. Cochrane Database of Systematic Reviews 2017;12:CD003633.
23. American Association of Neurological Surgeons. Dystonia.