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Homo-Amino Acids Provide Novel Options for Drug Discovery - AnaSpec, Inc. is a leading provider of integrated proteomics solutions for worldwide life science research.
Homo-Amino Acids Provide Novel Options for Drug Discovery

 

NewswireToday - /newswire/ - San Jose, CA, United States, 2006/10/16 - AnaSpec, Inc. is a leading provider of integrated proteomics solutions for worldwide life science research..

   
 
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The prefixing of “homo” to the name of an amino acid indicates the addition of a methylene (CH2) group on the a-carbon of an amino acid1,2. These are used for creating peptide analogs that have may have altered biological activity. An example is shown in Shimizu’s paper3 where certain amino acids in the parathyroid hormone peptide PTH (1-14) have been substituted with Aib (aminoisobutyric acid) and homoarginine. This shorter N-terminal fragment is found to be as potent as PTH (1-34) for stimulating cAMP formation in PTH-1 receptor-expressing cells.

AnaSpec, a leading provider of integrated proteomics solutions, provides a source of homo-amino acids suited for either drug discovery or investigation of peptide biological activity.

Homo-Amino Acids:

· Fmoc-homoarginine(Pbf)-OH
· Fmoc-S-trityl-L-homocysteine
· Boc-S-trityl-L-homocysteine
· Fmoc-L-homophenylalanine
· Fmoc-D-homophenylalanine
· Fmoc-homoproline-OH or Fmoc-Pip-OH

With a vision for innovation through synergy, AnaSpec offers expertise in three primary technologies: peptides, detection reagents, and combinatorial chemistry. AnaSpec carries a broad product line of biochemicals and reagents for basic research, high-throughput screening and drug discovery. In conjunction, AnaSpec provides premier custom services including peptide synthesis, antibody production, and assay development. AnaSpec holds a California Drug Manufacturing License (License #41747) and a FDA Registration for GMP Drug Manufacturing (Registration #2951078).

References:

1. Internet. Nomenclature and Symbolism for Amino Acids and Peptides.
2. IUPAC Commission on the Nomenclature of Organic Chemistry (CNOC). Nomenclature of Organic Chemistry, Section F: Natural Products and Related Compounds, Recommendations 1976, Eur. J. Biochem. 86, 1 (1978).
3. Shimizu, N. et al. J. Bone & Mineral Res. 19, 2078 (2004).

 
 
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Homo-Amino Acids Provide Novel Options for Drug Discovery

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Publisher Contact: Debra Thai 
408-452-5055 marketing[.]anaspec.com
 
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