NewswireToday - /newswire/ -
San Jose, CA, United States, 2006/09/18 - Myelin/oligodendrocyte glycoprotein (MOG) is a 26- to 28-kDa protein that was first described as a target antigen for the autoimmune demyelination response observed in animals immunized with CNS homogenates.
It is a member of the immunoglobulin superfamily expressed in the central nervous system (CNS) and located within the MHC. Found on the surface of myelinating oligodendrocytes and external lamellae of myelin sheaths in the CNS, it is thought to be targeted by the autoimmune T cell response in multiple sclerosis (MS). Although this protein is a minor component of myelin proteins, MOG is a potent autoantigen which contributes extensively to the anti-myelin response and primary inflammatory demyelination in autoimmune diseases. Several lines of evidence suggest that autoreactive antibodies are important in MS pathogenesis, however the pathophysiological significance of MOG-specific autoantibodies in MS/EAE is still controversial. Subtle changes in MOG sequences dramatically influence disease susceptibility and T cell responses in vitro.
In its continuing effort to provide research solutions for MS, AnaSpec offers MOG (35 - 55), mouse, rat, a key peptide that induces severe chronic experimental autoimmune encephalomyelitis in transgenic mice.
· MOG (35-55), mouse, rat
Other fragments of MOG (35-55)*:
· MOG 35-52
· MOG 35-53
· MOG 35-51
· MOG 38-55
· MOG 38-53
· MOG 40-55
· MOG 41-54
· MOG 42-54
· MOG 43-54
· MOG 45-54
· MOG 46-54
1. Delarasse, C. et al. J. Clin. Invest. 112, 544 (2003)
2. Pham-Dinh, D. et al. Proc. Natl. Acad. Sci. USA 3 90, 7990 (1993)
3. Carotenuto, A. et al. J. Med. Chem. 44, 2378 (2001)
4. Bernard, CC. et al. J. Mol. Med. 75, 77 (1997)
5. Iglesias, A. Glia 36, 220 (2001)
6. von Budingen, HC. et al. J. Clin. Immunol. 21, 155 (2001)