PRTODAY / NewswireToday Free press release distribution service network

Written by / Agency / Source: AnaSpec, Inc.

Check Ads Availability|e-mail Article


Are you the owner of this article?, Turn it PREMIUM with your LOGO instead - and make it 3rd party Ads-Free! within the next hour!

AnaSpec Introduces SensoLyte SIRT2 Assay Kits Fluorimetric - AnaSpec, Eurogentec Group, is pleased to release 2 assay kits for SIRT2, the SensoLyte® 520 FRET SIRT2 Assay Kit and the SensoLyte® Green SIRT2 Assay Kit
AnaSpec Introduces SensoLyte SIRT2 Assay Kits Fluorimetric

 

NewswireToday - /newswire/ - Fremont, CA, United States, 2011/02/14 - AnaSpec, Eurogentec Group, is pleased to release 2 assay kits for SIRT2, the SensoLyte® 520 FRET SIRT2 Assay Kit and the SensoLyte® Green SIRT2 Assay Kit.

   
 
Your Banner Ad Here instead - Showing along with ALL Articles covering Pharma/BioTech/Nutrition Announcements

Replace these Affiliate Programs at ANYTIME! Your banner here within the next hour. Learn How!


 

Expanding on our offerings of long wavelength, highly sensitive SIRT assays, AnaSpec, Eurogentec Group, is pleased to release 2 assay kits for SIRT2, the SensoLyte® 520 FRET SIRT2 Assay Kit and the SensoLyte® Green SIRT2 Assay Kit.

The substrate found in the SensoLyte® 520 FRET SIRT2 Assay Kit employs a FRET substrate, and the peptide sequence is derived from a human alpha-tubulin sequence surrounding the deacetylation site of SIRT2. The SensoLyte® Green SIRT2 Assay Kit provides a fluorogenic substrate with a human p53 derived sequence. Compared to lower emitting substrates found in existing commercial kits, these kits employ fluorimetric substrates that emit in the green range of 520 nm. At this higher wavelength, the contribution of autofluorescence is minimal. These kits provide a convenient, two-step homogeneous procedure for measuring sirtuin 2 activity and for screening enzyme inhibitors and activators.

In the first step, an acetylated substrate is incubated with sirtuin-containing samples. In the second step, deacetylated substrate is cleaved by the sirtuin developer, resulting in an increase of fluorescence that can be detected with excitation at 490 nm and emission at 520 nm. Fluorescence produced is proportional to SIRT2 activity.

Histone deacetylases (HDACs) act as transcriptional repressors of genes catalyzing the removal of acetyl groups from a ε-N-acetyl lysine of histone.1 Sirtuins comprise a unique class of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases (class III HDACs) that target multiple protein substrates to execute diverse biological functions. Sirtuins catalyze a reaction that couples lysine deacetylation to NAD hydrolysis, yielding O-acetyl-ADP-ribose and nicotinamide.2

Sirtuin 2 (SIRT2) belongs to the family of Sir2 (Silent Information Regulator 2) proteins. Substrates for SIRT2 are not limited to histones, but also include various transcription factors such as forkhead box (FOXO) transcription factors (FOXO1, FOXO3a) that modulate metabolic, cell cycle and cell death related pathways.3, 4 Other prominent substrates include the tumor suppressor p53 and alpha-tubulin.5, 6 Human SIRT2 is a cytoplasmic protein that increases in abundance during mitosis and regulates major events of cytokinesis.7

References:
1. Sterner, DE. et al. Microbiol. Mol. Biol. Rev. 64, 435 (2000).
2. Longo, V and Kennedy, B. Cell. 126, 257 (2006).
3. Wang, F. et al. Aging Cell 6, 505 (2007).
4. Jing, E. et al. Cell Metab. 6, 105 (2007).
5. Jin, Y.-H. et al. Biochem. Biophys. Res. Commun. 368, 690 (2008).
6. Inoue, T. et al. Cell Cycle 6(9) (2007) .
7. Dryden, S. et al. Mol. Cell. Biol. 23, 3173 (2003).

AnaSpec, Eurogentec Group
AnaSpec, Eurogentec Group (anaspec.com) is a leading provider of integrated proteomics and genomics solutionsTM for worldwide life science research. AnaSpec offers expertise in peptides, detection reagents, antibodies, assay kits, amino acids, oligonucleotides, and qPCRs. AnaSpec carries a broad product line of biochemicals and reagents for basic research, high-throughput screening and drug discovery. AnaSpec also provides premier custom services including peptide synthesis, antibody production, assay development, fluorescent dyes, and oligonucleotide synthesis. AnaSpec is certified to ISO 9001:2008.

 
 
Your Banner Ad Here instead - Showing along with ALL Articles covering Pharma/BioTech/Nutrition Announcements

Replace these Affiliate Programs at ANYTIME! Your banner here within the next hour. Learn How!


 

Written by / Agency / Source: AnaSpec, Inc.

 
 

Availability: All Regions (Including Int'l)

 

Traffic Booster: [/] Quick Newswire Today Visibility Checker

 

Distribution / Indexing: [+]

 
 
# # #
 

 
  Your Banner Ad showing on ALL
Pharma/BioTech/Nutrition articles,
CATCH Visitors via Your Competitors Announcements!


AnaSpec Introduces SensoLyte SIRT2 Assay Kits Fluorimetric

Company website links NOT available to basic submissions
It is OK to republish and/or LINK any newswire for any legitimate media purpose as long as you name Newswire Today and LINK as the source.
 
  Is this your article?
Activate ALL web links and social stream by Upgrading to Press Release PREMIUM Plan Now!

|
Publisher Contact: Tiffany Kao - AnaSpec.com 
510-791-9560
 
Newswire Today - PRZOOM / PRTODAY disclaims any content contained in this article. If you need/wish to contact the company who published the current release, you will need to contact them - NOT us. Issuers of articles are solely responsible for the accuracy of their content. Our complete disclaimer appears here.
IMPORTANT INFORMATION: Issuance, publication or distribution of this press release in certain jurisdictions could be subject to restrictions. The recipient of this press release is responsible for using this press release and the information herein in accordance with the applicable rules and regulations in the particular jurisdiction. This press release does not constitute an offer or an offering to acquire or subscribe for any AnaSpec, Inc. securities in any jurisdiction including any other companies listed or named in this release.

Pharma/BioTech/Nutrition via RSSAdd NewswireToday - PRZOOM Headline News to FeedBurner
Find who RetweetFollow @NewswireTODAY



Are you the owner of this article?, Turn it PREMIUM with your LOGO instead - and make it 3rd party Ads-Free! within the next hour!


Read Latest Articles From AnaSpec, Inc. / Company Profile


Read Pharma/BioTech/Nutrition Most Recent Related Newswires:

BD Expands Suite of Blood Culture Offerings with New BD BACTEC™ Standard Aerobic & Standard Anaerobic Plastic Bottles
Twist Bioscience Collaborates with Synbio Technologies to Supply Long DNA to Customers
FDA Grants Priority Review and Breakthrough Therapy Designation for Zelboraf (vemurafenib) in Erdheim-Chester Disease with BRAF V600 Mutation
Ipsen Receives Positive CHMP Opinion for Approval of Xermelo® (telotristat Ethyl)
BD Receives FDA 510(k) Clearance for New Immunological Diagnostic System
Positive Phase III Results for Genentech’s Emicizumab in Hemophilia A Published in The New England Journal of Medicine
Somatuline® Autogel® 120 Mg Receives Japanese Approval for A New Indication for the Treatment of Gastro-entero-pancreatic Neuroendocrine Tumors
OTC Topical Drugs Market Size will Grow Profitably in the Near Future 2017-2025 Finds PMR
Bioinformatics Market Size to Expand at 20.4% CAGR through 2020 Reports Persistence Market Research
Australia Nitric Acid Market Expected to Reach at Value of $1.3B by 2024 End Says PMR
Commodity Chemicals Market Projected to be Resilient by 2020 Says Persistence Market Research
Cell Expansion Market Set to Garner Staggering Revenues by 2025 Reports PMR
Soft Tissue Sarcoma Treatment Market Revenue Predicted To Go Up by 2025 Finds Persistence Market Research
Persistence Market Research Publishes Biopharmaceutical Membrane Filtration Market Forecast Over 2017-2025
Global Tablet Processing & Packaging Equipment Market to Reach USD 5,268.8 Million by 2022

Boost Your Social Network
& Crowdfunding Campaigns


LIFETIME SOCIAL MEDIA WALL
NewswireToday Celebrates 10 Years in Business


PREMIUM Members


Visit  MagLar, Inc.

Visit  S&A Capital Partner Ltd





 
  ©2017 Newswire Today — Limelon Advertising, Co.
Home | About | Advertise/Pricing | Contact | Investors | Privacy/TOS | Sitemap | FRANCAIS
newswire, PR press releases distribution service magazines engine news alert newsroom press room breaking news public relations articles company news alerts newswiredistribution ezine bizentrepreneur biznewstoday digital business report market search pr firms agencies reports distri-bution today investor relation successful internet entrepreneurs newswire distribution prtoday.com freenewswiredistribution asianewstoday bizwiretoday USA pr UK today - NOT affiliated with PRNewswire as we declined their partnership offer in 2013
 
PRTODAY & NewswireTODAY are NOT affiliated with USA TODAY (usatoday.com)