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Honolulu, HI, United States, 2006/09/11 - Bioactive glass is currently regarded as the most biocompatible material in the bone regeneration field because of its bioactivity, osteoconductivity and even osteoinductivity.
However, the formulation of bioactive glass has been limited to bulk, crushed powders and micronscale fibers. Now, researchers in South Korea and the UK have for the first time fabricated bioactive glass in nanofibrous form. This material, which shows excellent bioactivity, is likely to open the door to the development of new nano-structured bone regeneration materials for regenerative medicine and tissue engineering.
Materials for biomedical applications have been exploited to augment and regenerate human tissues that have been subjected to damage and diseases. Over the last decade the demands on synthetic biomaterials have increased significantly and considerable effort has been devoted to the area of biomaterials and tissue engineering.
Specifically for hard-tissue applications, such as the regeneration and repair of bones and teeth, several bioactive or bioinert materials have been used clinically. Silica-based bioglasses constitute the essential part of such bioactive materials, having already been utilized in numerous orthopedic and dental applications.
Professor Hae-Won Kim from the Department of Dental Biomaterials at Dankook University in South Korea, explained the benefits of bioglass to Nanowerk: "Most in vivo studies on bioglasses have confirmed their excellent biocompatibility with hard and even soft tissues. This is attributed mainly to their ability to form a bioactive layer at the interface in contact with living tissues, namely the hydroxycarbonate apatite (HCA) layer, which is equivalent to the mineral phase of human hard tissues. Based on extensive research conducted in vitro and in vivo, bioactive glasses are considered as one of the most-promising biomaterials for the 'next generation'."
Read the full article on the Nanowerk website.
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By Michael Berger, Copyright 2006 Nanowerk LLC