NewswireToday - /newswire/ -
San Jose, CA, United States, 2006/08/14 - AnaSpec has been providing b-Amyloid peptides to leading Alzheimer’s researchers for almost 10 years. As interest in amyloid peptides continues to grow, AnaSpec has developed an extensive selection of catalog amyloid peptides to match that interest.
AnaSpec, Inc. is a leading provider of integrated proteomics solutions for worldwide life science research. With a vision for innovation through synergy, AnaSpec offers expertise in three primary technologies: peptides, detection reagents, and combinatorial chemistry. AnaSpec carries a broad product line of biochemicals and reagents for basic research, high-throughput screening and drug discovery. In conjunction, AnaSpec provides premier custom services including peptide synthesis, antibody production, and assay development. AnaSpec holds a California Drug Manufacturing License (License #41747) and a FDA Registration for GMP Drug Manufacturing (Registration #2951078).
Equipped with expertise in both peptide synthesis and detection technologies, AnaSpec presents one of the world’s most comprehensive collection of amyloid peptides.
ß-Amyloid (Aß) peptides, made up of long, insoluble ordered fibers, are glycoproteins deposited extracellularly in tissues in amyloidosis. These peptides are generated as cleavage products from the membrane protein, Amyloid Precursor Protein (APP) by two proteases, b-secretase and g-secretase. Aßs are amphiphilic peptides with a hydrophilic N-terminal domain (residues 1 to 28) and a hydrophobic C-terminal (residues 29 to 40), the latter corresponding to a part of the transmembrane domain of APP. These insoluble amyloid deposits found in Alzheimer’s diseased brains have been the subject of increased interest for Alzheimer’s treatment (reviewed in 1, 2).
The AnaSpec collection includes:
· Aßs of various lengths
· Amino acid-substituted Aßs
· Dye-labeled Aßs
· Biotin-labeled Aßs
· TFA salt forms (Standard form, unless otherwise specified)
· Sodium forms
· HCl forms
· iAb5p and other-Aß inhibitors
· Secretase fluorescent resonance energy transfer (FRET) substrates and inhibitors
· APP Fragments
Full listing of amyloid peptides available at our website.
1. Selkoe DJ. Nature 399, A23 (1999).
2. Suh, Y-H. and F. Checler. Pharma. Rev. 54, 469 (2002).