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Otava Ltd Introduces High-throughput Screening Compound Libraries - To identify promising leads for potentially marketable drugs requires large compound libraries. In this white paper we would like to discuss some aspects of high-throughput screening (HTS) compound libraries used in drug discovery process
Otava Ltd Introduces High-throughput Screening Compound Libraries

 

NewswireToday - /newswire/ - Kyiv, Kyivska, Ukraine, 2010/08/19 - To identify promising leads for potentially marketable drugs requires large compound libraries. In this white paper we would like to discuss some aspects of high-throughput screening (HTS) compound libraries used in drug discovery process.

   
 
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High-throughput screening (HTS) is an automated technique effectively used to rapidly scan and analyze such libraries. The purpose of HTS is to cross-examine large chemical collections in the context of a biological target to accurately identify active compounds that can be used as starting points for further chemical optimization and drug development. HTS allows screening chemical libraries containing several million compounds within a few days.

Quantities as well as quality of compound libraries are key factors in HTS. Chemical compounds need to satisfy a variety of constraints before they become marketable drugs. For example, a common design approach is focusing around Lipinski’s rules that describe common molecular properties of many currently marketed drugs.

Using OTAVA In-house Stock Compounds (about 160,000 compounds) and OTAVA Tangible Compounds (185,000 compounds) is a unique opportunity to enrich your company's collection of compounds for screening purposes. OTAVA’s Drug-like Green Collection consisting of more than 90,000 compounds was prepared on the basis of In-house Stock Library and pre-formatted using Lipinski’s Rules of Five.

Using OTAVA’s In-house Stock Collection a number of focused libraries have been designed:

• docking-based, SAR-based, disease-based and protein families libraries.
• OTAVA’s combinatorial libraries have been developed to meet the needs of researchers by harnessing the quality and structural diversity you have come to expect from OTAVA products.

For more information visit otavachemicals.com/.

 
 
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Written by / Agency / Source: Otava Ltd

 
 

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Otava Ltd Introduces High-throughput Screening Compound Libraries

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Publisher Contact: Andrey Dmytrenko - OtavaChemicals.com 
+380 44 5222458 info[.]otavachemicals.com
 
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IMPORTANT INFORMATION: Issuance, publication or distribution of this press release in certain jurisdictions could be subject to restrictions. The recipient of this press release is responsible for using this press release and the information herein in accordance with the applicable rules and regulations in the particular jurisdiction. This press release does not constitute an offer or an offering to acquire or subscribe for any Otava Ltd securities in any jurisdiction including any other companies listed or named in this release.

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