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Int'l Stem Cell Corp. and India Eye Hospital Developing Stem Cell-Based Treatment for Corneal Vision - International Stem Cell Corporation and Sankara Nethralaya Eye Hospital, a nonprofit medical facility, are collaborating to develop ISCO's 'CytoCor™' stem cell-derived corneal tissue. The goal is to use CytoCor, human tissue derived from pluripotent
Int'l Stem Cell Corp. and India Eye Hospital Developing Stem Cell-Based Treatment for Corneal Vision

 

NewswireToday - /newswire/ - Los Angeles, CA, United States, 2010/07/09 - International Stem Cell Corporation and Sankara Nethralaya Eye Hospital, a nonprofit medical facility, are collaborating to develop ISCO's 'CytoCor™' stem cell-derived corneal tissue. The goal is to use CytoCor, human tissue derived from pluripotent.

   
 
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International Stem Cell Corporation (OTCBB: ISCO), and Sankara Nethralaya Eye Hospital, a nonprofit medical facility, announced commencement of a collaboration to develop ISCO's 'CytoCor™' stem cell-derived corneal tissue. The goal is to use CytoCor to treat corneal blindness and vision impairment.

CytoCor consists of transparent human tissue derived from pluripotent human stem cells. These structures are produced in the laboratory and recent testing at Sankara Nethralaya and laboratories in the US has demonstrated a range of structural, biochemical and refractory properties characteristic of human cornea.

'This is one more step in ISCO's stated plan of building its portfolio of therapeutic agents through strategic alliances throughout the world,” said Chairman, Ken Aldrich.

CytoCor may offer a first-in-class opportunity for high-quality, cost-efficient transplantation tissue for the 10 million people world-wide suffering from corneal vision impairment, particularly in India and the rest of Asia, as well as in Europe. Standardized tissues derived from pluripotent stem cells, such as the CytoCor tissue, could eliminate the current problem that corneal tissue derived from donors may harbor diseases that could be transferred from the donor to the recipient. It may also provide a much needed alternative to the use of live and extracted animal eyes in the $500+million market for safety testing of drugs, chemicals and consumer products.

According to Professor Dr. S. Krishnakumar, “Sankara Nethralaya is dedicated to the development and application of new state-of-the-art ophthalmic technologies. The need for high-volume, high-quality human corneal tissue is substantial, not only in India but across Asia and much of Europe. We appreciate the opportunity to join ISCO in their pursuit to create a new standard of care for the treatment of human corneal disease.” Initially, Dr. Krishnakumar and his team will be using the CytoCor tissue in preclinical studies to explore the ability of the tissue to withstand sutures and bio-compatible glues in order to validate the potential of the tissue for use in animal or human clinical trials.

According to Dr. Geetha Krishnan Iyer, who is involved in the management of ocular surface disease at Sankara Nethralaya, 'The team at Sankara Nethralaya is pleased to collaborate with ISCO on stem cell-derived corneal tissue. In vitro studies to evaluate safety and efficacy of the tissue, as well as surgical feasibility tests will be carried out, following which there could be clinical application in lamellar keratoplasty using the above mentioned tissue. With improvements in surgical techniques over the past few years, the indications for anterior lamellar keratoplasty have expanded significantly. With high demand for donor corneal tissue for the same but limited availability, there is definitely scope for utilizing ISCO's corneal tissue following relevant tests.”

Jeffrey Janus, Senior VP of Operations at ISCO, states: 'This collaboration with the excellent team of scientists and clinicians at Sankara Nethralaya has already proven to be productive. Sankara's ophthalmology expertise and ISCO's cell culture capabilities constitute a perfect match to perfect and advance CytoCor tissue towards future use in treating corneal disease and injuries.”

About International Stem Cell Corporation (ISCO.Ob)
International Stem Cell Corporation (Intlstemcell.com) is a California-based biotechnology company focused on therapeutic and research products. ISCO's core technology, parthenogenesis, results in creation of pluripotent human stem cells from unfertilized oocytes (eggs). These proprietary cells avoid ethical issues associated with use or destruction of viable human embryos and, unlike all other major stem cell types, can be immune matched and be a source of therapeutic cells with minimal rejection after transplantation into hundreds of millions of individuals across racial groups. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology and is developing a line of cosmeceutical products via its subsidiary Lifeline Skin Care. ISCO is advancing novel human stem cell-based therapies where cells have been proven to be efficacious but traditional small molecule and protein therapeutics have not. More information is available at ISCO's website.

About Sankara Nethralaya
Sankara Nethralaya was founded as a not-for-profit eye hospital in Chennai, India, in 1978. This mission of “non-commercial medicine” has continued until today when the organization has expanded its clinical practice to many regions of India and grown into a superior specialty institution for ophthalmic care and world-leading eye research. Sankara Nethralaya’s hospitals see 1,600 eye patients and do over 100 eye surgeries each day, often free to the patients. For example, in its main Chennai operating center, about 15,000 cataract surgeries are performed free of cost each year, amounting to 50% of all cataract surgeries done in Chennai the complex. On the research side, Sankara Nethralaya employs sixty scientists and clinicians dedicated to the basic and applied research and development and application of new state-of-the-art ophthalmic technologies. Sankara Nethralaya is serious about both reach and quality, e.g. they have trained over 300 ophthalmologists all over India and they were the first ISO 9002 certified Eye Hospital in Asia.

Forward-Looking Statements
Statements pertaining to anticipated technological developments and therapeutic applications, the potential benefits of collaborations, and other opportunities for the company and its subsidiaries, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates,") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products and the management of collaborations, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

 
 
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Int'l Stem Cell Corp. and India Eye Hospital Developing Stem Cell-Based Treatment for Corneal Vision

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