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The performance Limits of Nanobiosensors - Nanoscale sensors based on silicon nanowires and carbon nanotubes are capable of detecting molecules at ultra low concentrations. The potential applications include early detection of cancer and fast sequencing of genome.
The performance Limits of Nanobiosensors

 

NewswireToday - /newswire/ - Honolulu, HI, United States, 2006/07/19 - Nanoscale sensors based on silicon nanowires and carbon nanotubes are capable of detecting molecules at ultra low concentrations. The potential applications include early detection of cancer and fast sequencing of genome..

   
 
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However, for these applications, the time taken by the sensor to reach stable response is crucial. This time is dictated by the diffusion of molecules (e.g. cancer markers) through the solution and their subsequent capture at the sensor surface. Researchers at Purdue University show that this response is governed by the geometry of diffusion of the system and that nanobiosensors are capable of detecting bio-molecules at much lower concentration (up to 4-5 orders of magnitude) than the classical planar sensors (ISFETs or CHEMFETs).

Based on electrostatics considerations, it is well known that nanowires are more sensitive to adsorbed charges e.g., DNA or protein, compared to ISFET or CHEMFET sensors. This classical view of nanosensor response, however, misses the kinetic part of the detection process, i.e., when a sensor is inserted in a solution of target biomolecules, the time to capture a certain number of biomolecules also depends on the dimensions of the sensor.

Read the full story on the Nanowerk website.

About Nanowerk

Nanowerk is a leading nanotechnology information portal. Apart from its unique Nanomaterial Database™, with over 1,300 products from 90 suppliers, it provides the most complete nanotech events calendar; hundreds of links to universities, labs, researchers, associations, networks and international initiatives involved in nanotechnology; daily news; downloadable reports; and much more. The site includes a daily “Spotlight” section featuring Nanowerk-exclusive reviews and summaries of cutting-edge nanotechnology research by guest authors and Nanowerk editors. Nanowerk also publishes the nanoRISK newsletter – a constructive contribution to the debate about the potential risks of nanotechnology.

 
 
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The performance Limits of Nanobiosensors

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Publisher Contact: Michael Berger - Nanowerk.com 
1-808-741-1739 michael[.]nanowerk.com
 
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