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Honolulu, HI, United States, 2006/07/18 - Researchers in South Korea used single-walled carbon nanotubes (SWNTs) to tag single-stranded DNA to locate a particular sequence of DNA within a complex genome..
The results show that SWNTs may be used as generic nano-biomarkers for the precise detection of specific kinds of genes.
Organic fluorophores have been widely used to tag bio-molecules in bio-imaging technologies. However, these fluorophores have several limitations, such as photobleaching, that restrict their utility in applications such as cell proliferation, stem-cell differentiation, and realtime microscopy experiments lasting several hours. Photobleaching of the chromophore limits the ability of investigators to observe their specimens repeatedly and over long periods.
The strong Raman signals and fluorescence emissions emitted from SWNTs do not blink or photobleach under prolonged excitation, which is an advantage in optical nano-biomarker applications.
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By Michael Berger, Copyright 2006 Nanowerk LLC. All rights reserved.