PRTODAY / NewswireToday Free press release distribution service network

Written by / Agency / Source: ReachBio, LLC

Check Ads Availability|e-mail Article


Are you the owner of this article?, Turn it PREMIUM with your LOGO instead - and make it 3rd party Ads-Free! within the next hour!

ReachBio Launches HemoRANK-TKI Service Package for Predicting Myelotoxicity - In vitro test ranks novel compounds against approved tyrosine kinase inhibitors for likelihood to cause clinical neutropenia - ReachBio.com
ReachBio Launches HemoRANK-TKI Service Package for Predicting Myelotoxicity

 

NewswireToday - /newswire/ - Seattle, WA, United States, 2009/09/15 - In vitro test ranks novel compounds against approved tyrosine kinase inhibitors for likelihood to cause clinical neutropenia - ReachBio.com.

   
 
Your Banner Ad Here instead - Showing along with ALL Articles covering Pharma/BioTech/Nutrition Announcements

Replace these Affiliate Programs at ANYTIME! Your banner here within the next hour. Learn How!


 

ReachBio, LLC announced today the launch of HemoRank™-TKI, an in vitro assay service package that helps predict the potential of novel therapeutic tyrosine kinase inhibitors (TKIs) to cause clinical hematotoxicity (myelotoxicity or neutropenia). This assay system is designed to help biotechnology and pharmaceutical companies that are developing novel therapeutic TKIs gain insight into the likelihood and degree to which their compounds might cause neutropenia in patients and thus aid in lead candidate selection, structure-toxicity relationship research, and other areas of non-clinical and investigative toxicology research.

The HemoRank™-TKI contract assay service package is a standardized test system in which one or more novel TKIs are run in robust in vitro human bone marrow progenitor assays (CFU-GM assays) in parallel with a standard panel of up to 6 TKIs that are currently approved for therapeutic use. The TKIs available for the standard panel (Lapatinib, Erlotinib, Sorafenib, Imatinib, Sunitinib and Dasatinib) have known different levels of clinical myelotoxicity, as reported in the medical literature. The rank order of in vitro IC50 values for these compounds obtained by the HemoRank™ system correlates with the degree to which they cause neutropenia in the clinic. Novel compounds tested within the system are ranked against the standard panel and informed predictions can then be made regarding the likely level of clinical neutropenia they will cause. Testing against a reduced panel of the client’s choosing or against blinded or unblinded controls provided directly by the client is also an option.

According to Dr. Emer Clarke, Chief Scientific Officer for ReachBio, “we have found that in our hands, the in vitro human CFU-GM assay is both very reproducible and highly predictive of clinical myelotoxicity for a variety of different compound classes, including kinase inhibitors. Specifically for the marketed TKIs that we tested during the development of the HemoRANK-TKI service package, the rank order of the in vitro IC50 values that we generated correlated extremely well with the degree that these compounds have been reported to cause clinical myelotoxicity – with an R2 value of 0.81. We believe that this type of correlation between the in vitro and clinical findings allows the system to be used to rank the myelotoxic potential of novel TKIs against the members of the same drug class that are currently on the market and to therefore predict the potential incidence, degree and severity of clinical neutropenia that the novel compounds might be expected to cause.”

Dr. Eric Atkinson, president of BroadReach BioSystems and strategic advisor to ReachBio, added: “There’s often a balance between drug toxicity and efficacy, and the tipping point can shift, depending upon the disease indication. As a drug class, TKIs are known to have significant myelotoxic liabilities. However, these drugs are currently being used to treat patients with certain types of cancer, and when life-threatening diseases like that are being treated, a certain degree of drug-induced neutropenia is going to be acceptable – although it’s definitely an advantage to have as low a myelotoxic potential as possible even for oncology indications, since significant myelotoxicity will be dose-limiting. An emerging issue in the TKI space, however, is that these compounds have a lot of potential to be used in inflammation and other immune system diseases. The life-threatening potential of these types of diseases is generally lower than that of cancer, so the risk/benefit equation changes and the bar for an acceptable degree of toxicity will be higher. There will therefore be more and more pressure on companies developing TKIs for non-oncology applications to come up with compounds with lower levels of myelotoxicity. Being able to accurately predict the myelotoxic potential of new TKIs and especially being able to rank the potential clinical neutropenia in relation to the degree of neutropenia already established for marketed drugs of the same class, such as ReachBio’s new HemoRANK-TKI test offers, is going to be extremely useful during the development of new TKIs for both oncology and non-oncology indications.”

About ReachBio
ReachBio, LLC (reachbio.com) is a boutique life sciences organization based in Seattle, WA. It provides specialized contract assays, contract research, educational and consulting services to pharmaceutical, biotechnology, agrichemical, and related organizations worldwide. The company’s focus is on the clinical, industrial and research uses of primary cell biology - in particular the use of stem cell and progenitor cell assays and model systems for high value applications such as drug screening and drug discovery.

 
 
Your Banner Ad Here instead - Showing along with ALL Articles covering Pharma/BioTech/Nutrition Announcements

Replace these Affiliate Programs at ANYTIME! Your banner here within the next hour. Learn How!


 

Written by / Agency / Source: ReachBio, LLC

 
 

Availability: All Regions (Including Int'l)

 

Traffic Booster: [/] Quick Newswire Today Visibility Checker

 

Distribution / Indexing: [+]

 
 
# # #
 

 
  Your Banner Ad showing on ALL
Pharma/BioTech/Nutrition articles,
CATCH Visitors via Your Competitors Announcements!


ReachBio Launches HemoRANK-TKI Service Package for Predicting Myelotoxicity

Company website links NOT available to basic submissions
It is OK to republish and/or LINK any newswire for any legitimate media purpose as long as you name Newswire Today and LINK as the source.
 
  Is this your article?
Activate ALL web links and social stream by Upgrading to Press Release PREMIUM Plan Now!

|
Publisher Contact: Rob Chaney - ReachBio.com 
206-420-0300 rob.chaney[.]reachbio.com
 
Newswire Today - PRZOOM / PRTODAY disclaims any content contained in this article. If you need/wish to contact the company who published the current release, you will need to contact them - NOT us. Issuers of articles are solely responsible for the accuracy of their content. Our complete disclaimer appears here.
IMPORTANT INFORMATION: Issuance, publication or distribution of this press release in certain jurisdictions could be subject to restrictions. The recipient of this press release is responsible for using this press release and the information herein in accordance with the applicable rules and regulations in the particular jurisdiction. This press release does not constitute an offer or an offering to acquire or subscribe for any ReachBio, LLC securities in any jurisdiction including any other companies listed or named in this release.

Pharma/BioTech/Nutrition via RSSAdd NewswireToday - PRZOOM Headline News to FeedBurner
Find who RetweetFollow @NewswireTODAY



Are you the owner of this article?, Turn it PREMIUM with your LOGO instead - and make it 3rd party Ads-Free! within the next hour!


Read Latest Articles From ReachBio, LLC / Company Profile


Read Pharma/BioTech/Nutrition Most Recent Related Newswires:

Frost & Sullivan Commends Nemaura for Developing Superior Transdermal Drug Delivery Technology Platforms, the Memspatch and Micropatch
Greenphire Sponsors Second Annual Clinical Trial Agreements, Investigator Payments and Fair Market Value Meeting
Genentech’s Gazyva Helped People with Previously Untreated Follicular Lymphoma Live Significantly Longer
BD Announces Adoption of Windows 10 ‘Internet of Things’ for the Pyxis™ ES System
Greenphire Named to Deloitte 2016 Technology Fast 500™
Genentech Showcases New Clinical Data Across a Variety of Blood Diseases at American Society of Hematology 2016 Annual Meeting
BD Collaborates with JDRF to Focus on Extended Wear Innovations for Insulin Infusion Delivery
BD Launches First Syringe Designed for Use with Humulin® R U-500 Insulin
MDxHealth Announces Unique CPT Code Awarded for ConfirmMDx from the American Medical Association
BD MAX™ Vaginal Panel Receives FDA Market Authorization to Detect Most Common Causes of Vaginal Infections
Greenphire Receives EU-US Privacy Shield Certification
The 2016 Georges Mathé Prize Recognizes Research on the Immunological Determinants of the Response to Breast Cancer Treatment
MDxHealth Announces Agreement with HIFU CLINIC Prostate Cancer Center for Distribution of SelectMDx in Poland
First Patient in Malaysia Receives TheraSphere™ Radioembolisation Therapy
FDA Approves Genentech’s Lucentis® (Ranibizumab Injection) Prefilled Syringe

Boost Your Social Network
& Crowdfunding Campaigns


LIFETIME SOCIAL MEDIA WALL
NewswireToday Celebrates 10 Years in Business


PREMIUM Members


Visit  La Bella Bakery Artisan Bakery Arizona

Visit  Triggr & Bloom





 
  ©2016 Newswire Today — Limelon Advertising, Co.
Home | About | Advertise/Pricing | Contact | Investors | Privacy/TOS | Sitemap | FRANCAIS
newswire, PR free press releases distribution service magazines engine news alert newsroom press room breaking news public relations articles company news alerts newswiredistribution ezine bizentrepreneur biznewstoday digital business report market search pr firms agencies reports distri-bution today investor relation successful internet entrepreneurs newswire distribution prtoday.com freenewswiredistribution asianewstoday bizwiretoday USA pr UK today - NOT affiliated with PRNewswire as we declined their partnership offer in 2013
 
PRTODAY & NewswireTODAY are NOT affiliated with USA TODAY (usatoday.com)