PRTODAY / NewswireToday Free press release distribution service network

More news: Nanotechnology
Written by / Agency / Source: Nanowerk, LLC

Check Ads Availability|e-mail Article


Are you the owner of this article?, Turn it PREMIUM with your LOGO instead - and make it 3rd party Ads-Free! within the next hour!

Repairing the Heart with Cell Therapy and Nanofibers - The human heart does not have significant regeneration capabilities and cardiologists look to cell therapy as a promising new method for cardiac repair. Now there is a new delivery system that improves the results of cell therapy.
Repairing the Heart with Cell Therapy and Nanofibers

 

NewswireToday - /newswire/ - Honolulu, HI, United States, 2006/05/24 - The human heart does not have significant regeneration capabilities and cardiologists look to cell therapy as a promising new method for cardiac repair. Now there is a new delivery system that improves the results of cell therapy..

   
 
Your Banner Ad Here instead - Showing along with ALL Articles covering Nanotechnology Announcements

Replace these Affiliate Programs at ANYTIME! Your banner here within the next hour. Learn How!


 

The new system allows greater control of the intramyocardial environment (inside the heart muscle) by delivering growth factors to an injured heart muscle and using peptide nanofibers for prolonged delivery of the injected factor.

Dr. Richard T. Lee, a cardiologist at Harvard Medical School's Brigham and Women's Hospital (BWH), explained their recent research to Nanowerk: "One of the big problems with cell therapy is that once you inject cells into the body, you lose control over their environment. In the laboratory, we have tight control of conditions and can add growth factors, for example, whenever we want. The main finding of our study is that you can delivery growth factors to the environment around injected cells using nanofibers."

Dr. Lee's recent paper, titled "Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction" was published in the May 12, 2006 online edition of Proceedings of the National Academy of Sciences (PNAS). The paper was first authored by Michael E. Davis and co-authored by collaborators from BWH and the Division of Biological Engineering at MIT.

"Most past studies inject proteins directly into tissues like the heart" Lee says. "Many proteins delivered this way don't stay in the tissue very long. Our new technology allows the growth factor to be delivered for many weeks in a highly controlled way."

Repairing the heart by using cell therapy is a very promising new approach to cardiac repair. However, studies to date indicate that few transplanted cells engraft and ultimately function normally within the host tissue. The shortcoming of many therapeutic strategies is the lack of quantitative control of transplanted cells in their new environment.

Substantial data suggest that insulin-like growth factor 1 (IGF-1) is a potent cardiomyocyte growth and survival factor. IGF-1 overexpression increases cardiac stem cell number and growth, leading to an increase in myocyte turnover and function in the aging heart. However, IGF-1 is a small protein that diffuses readily through tissues, which restricts its retention within these tissues for prolonged periods.

Self-assembling peptides are oligopeptides (polypeptides less than 30-50 amino acids long) composed of alternating hydrophilic and hydrophobic amino acids. On exposure to physiological osmolarity and pH, the peptides rapidly assemble into small nanofibers (10 nm) that can be injected into the heart muscle to form 3D cellular microenvironments. These peptide nanofiber microenvironments recruit a variety of cells including vascular cells.

Lee explains: "In our article, we describe development of a delivery system using a "biotin sandwich" approach that allows coupling of a growth factor to peptide nanofibers without interfering with self-assembly. Biotinylation of self-assembling peptides allowed specific and highly controlled delivery of IGF-1 to local myocardial microenvironments, leading to improved results of cell therapy."

"Although we describe controlled myocardial delivery here, this approach may be used to delivery one factor or even multiple factors to tissues for prolonged periods" Lee says.
This ability to control the local myocardial microenvironment may prove critical to preventing heart failure.

Lee concludes: "We think this is just the beginning of how we can design the local environment around cells to encourage them to do things that can help the injured tissue. We just delivered one factor, but there's no reason you can't deliver many factors that are needed."

By Michael Berger, Copyright 2006 Nanowerk LLC. All rights reserved.

 
 
Your Banner Ad Here instead - Showing along with ALL Articles covering Nanotechnology Announcements

Replace these Affiliate Programs at ANYTIME! Your banner here within the next hour. Learn How!


 

Written by / Agency / Source: Nanowerk, LLC

 
 

Availability: All Regions (Including Int'l)

 

Traffic Booster: [/] Quick Newswire Today Visibility Checker

 

Distribution / Indexing: [+]

 
 
# # #
 
 
  Your Banner Ad showing on ALL
Nanotechnology articles,
CATCH Visitors via Your Competitors Announcements!


Repairing the Heart with Cell Therapy and Nanofibers

Company website links NOT available to basic submissions
It is OK to republish and/or LINK any newswire for any legitimate media purpose as long as you name Newswire Today and LINK as the source.
 
  Is this your article?
Activate ALL web links and social stream by Upgrading to Press Release PREMIUM Plan Now!

|
Publisher Contact: Michael Berger - Nanowerk.com 
1-808-741-1739 michael[.]nanowerk.com
 
Newswire Today - PRZOOM / PRTODAY disclaims any content contained in this article. If you need/wish to contact the company who published the current release, you will need to contact them - NOT us. Issuers of articles are solely responsible for the accuracy of their content. Our complete disclaimer appears here.
IMPORTANT INFORMATION: Issuance, publication or distribution of this press release in certain jurisdictions could be subject to restrictions. The recipient of this press release is responsible for using this press release and the information herein in accordance with the applicable rules and regulations in the particular jurisdiction. This press release does not constitute an offer or an offering to acquire or subscribe for any Nanowerk, LLC securities in any jurisdiction including any other companies listed or named in this release.

Nanotechnology via RSSAdd NewswireToday - PRZOOM Headline News to FeedBurner
Find who RetweetFollow @NewswireTODAY



Are you the owner of this article?, Turn it PREMIUM with your LOGO instead - and make it 3rd party Ads-Free! within the next hour!


Read Latest Articles From Nanowerk, LLC / Company Profile


Read Nanotechnology Most Recent Related Newswires:

NEC Discovers 'Carbon Nanobrush' - The World's First Fibrous Aggregate of Carbon Nanohorns
Frost & Sullivan Commends RUSNANO for Accelerating the Russian Nanotechnology Industry with Its Unique Investment Strategy and Innovative Services
Imec and Crystal Solar Demonstrate 22.5 Percent nPERT Si Solar Cells on Kerfless Epitaxial Wafers
Nanomaterials for Printing Market Worth $1,974 Million by 2019 Reports MarketsAndMarkets
Nanotechnology in Medical Devices Market Worth $8.5 Billion by 2019 Finds MarketsandMarkets
Polymer Nanocomposites Market Worth $5,100 Million by 2020 Finds MarketsAndMarkets
First Speakers of EuroNanoForum 2015 Announced
OCSiAl Group Receives Frost & Sullivan Technology Innovation Award for its Game-Changing Carbon Nanotube Production Process
Elmo Features its NANO Ultra High Power Servo Drive at IAS 2014 in China
Carbodeon Ltd Oy Announces Improvements to Electroless Nickel Including A 3x Improvement in Wear Resistance
IMARC Group Publishes New Report Insights on Setting Up A Rare Earth Magnet Manufacturing Plant
Carbodeon Enables 20 Percent Increase in Polymer Thermal Filler Conductivity
Industry Veteran Fergus Clarke Joins Picodeon as CEO
Picodeon’s Pulsed Laser Deposition Technology Enables Microstructural Control
Imec Integrates CCD and CMOS Technology to Improve Performance of CMOS imagers

Boost Your Social Network
& Crowdfunding Campaigns


LIFETIME SOCIAL MEDIA WALL
NewswireToday Celebrates 10 Years in Business


PREMIUM Members


Visit  NAKIVO, Inc.

Visit  JobsWare.com





 
  ©2016 Newswire Today — Limelon Advertising, Co.
Home | About | Advertise/Pricing | Contact | Investors | Privacy/TOS | Sitemap | FRANCAIS
newswire, PR free press releases distribution service magazines engine news alert newsroom press room breaking news public relations articles company news alerts newswiredistribution ezine bizentrepreneur biznewstoday digital business report market search pr firms agencies reports distri-bution today investor relation successful internet entrepreneurs newswire distribution prtoday.com freenewswiredistribution asianewstoday bizwiretoday USA pr UK today - NOT affiliated with PRNewswire as we declined their partnership offer in 2013
 
PRTODAY & NewswireTODAY are NOT affiliated with USA TODAY (usatoday.com)