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San Jose, CA, United States, 2009/03/13 - AnaSpec has announced type I acidic keratin antibodies (keratin –10, -13 and -14) have been tested in applications such as western blots or IHC.
AnaSpec has announced the newest additions to its expanding line of keratin antibodies. These type I acidic keratin antibodies (keratin –10, -13 and -14) have been tested in applications such as western blots or IHC.
Intermediate filaments (IFs), together with actin microfilaments and tubulin microtubules, comprise the three major cytoskeletal networks that are found in most eukaryotic cells.1 Keratins, which are the largest IF protein subgroup, can be divided into the acidic type I (K9-K20) and basic type II (K1-K8) Keratins.2 Typically, epithelial cells express at least one of each type, and the proteins exist in the cells as noncovalent obligate heteropolymers. Keratin networks are highly dynamic and reorganized during cell differentiation, mitosis and apoptosis, and also play important cytoprotective and structural support roles for the cell.3,4
About AnaSpec, Inc.
AnaSpec (anaspec.com) is a leading provider of integrated proteomics solutions to the world’s largest biotech, pharmaceutical, and academic research institutions. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents, and combinatorial chemistry.
1. Ku, NO. et al. Am J. Physiol. 277, G1108 (1999).
2. Schweizer, J. et al. J. Cell Biol. 174, 169 (2006).
3. Omary, MB. et al. Trends Biochem. Sci. 31, 383 (2006).
4. Omary, MB. et al. N. Engl. J. Med. 351, 2087 (2004).