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Piscataway, NJ, United States, 2009/03/03 - International contract research organization GenScript Corporation has developed two recombinant protein expression technologies that can provide high levels of both protein expression and purity. 1548:HK
To date, BacuVance™ and YeastHIGH™ both show success rates of over 90%.
The BacuVance™ protein expression system employs insect cells infected by a high-titer recombinant baculovirus. BacuVance™ can fill orders of up to gram quantities of highly purified protein. The system's emphasis is on protein functionality, particularly with regard to eukaryotic proteins. Like most GenScript services, BacuVance™ can be tailored to each project's specific needs. In this case, GenScript offers a selection of different insect cell types for fine-tuned insect expression environment. In addition, clients can order transformed high-titer, baculovirus directly, delivered ready-to-use to produce proteins.
YeastHIGH™ is a yeast protein expression system producing proteins via high expression levels of genes of interest by selecting desired yeast transformants. The system uses durable, stable yeast strains whose protein processing resembles that of mammalian cells. This system has a very high yield and a capacity of up to 500L.
GenScript implements pre-project codon optimization and rare codon analysis for different insect cell lines and yeast strains. Both technologies give the client a number of options with regard to the initial input: full-length cDNA, EST sequence information, and genomic sequences. If genomic sequences are provided, the project implements GenScript mature gene synthesis platform.
Both YeastHIGH™ and BacuVance™ link to many downstream applications, including eukaryotic protein analysis, NMR studies on isotope-labeled proteins, assay screening, structural biology studies, animal feed production, and environmental engineering.
GenScript Corporation (genscript.com) is a reliable outsourcing partner providing a wide array of services to augment all stages of the drug discovery and biological reagent manufacturing processes, including high-quality gene synthesis and cloning, custom protein expression and purification, custom peptide synthesis and antibody development, custom stable cell line development, and a wide selection of biological reagents to life science researchers in industrial and academic settings. GenScript Corporation is headquartered in Piscataway, New Jersey.
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