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AnaSpec Introduces Industry’s First Fluorimetric Assay Kit for Aggrecanase-1 Activity Detection - AnaSpec has announced the release of the industry’s first fluorimetric assay optimized to detect ADAMTS-4 (aggrecanase-1) activity - the SensoLyte™ 520 Aggrecanase-1 Assay Kit
AnaSpec Introduces Industry’s First Fluorimetric Assay Kit for Aggrecanase-1 Activity Detection

 

NewswireToday - /newswire/ - San Jose, CA, United States, 2008/12/15 - AnaSpec has announced the release of the industry’s first fluorimetric assay optimized to detect ADAMTS-4 (aggrecanase-1) activity - the SensoLyte™ 520 Aggrecanase-1 Assay Kit.

   
 
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A FRET based assay, it is homogeneous and has an emission in the green range (Ex/Em= 490 nm/520 nm). The kit contains a novel internally quenched peptide substrate for aggrecanase-1 consisting of 5-FAM/TAMRA as the FRET pair. In the intact FRET peptide, the fluorescence of 5-FAM is quenched by TAMRA. Active ADAMTS4 cleaves FRET substrate into two separate fragments resulting in an increase of 5-FAM fluorescence. Other members of aggrecanase family, such as ADAMTS-1 and ADAMTS-5, do not cleave the substrate provided in this kit.

Aggrecanases are members of the ADAMTS (A Disintegrin And Metalloprotease with Thrombospondin motif) family of proteases. ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) activities result in the degradation of cartilage aggrecan in arthritic diseases.1-3 ADAMTS-4 (aggrecanase-1) is a major aggrecanase in human osteoarthritic cartilage.4 Other members of the ADAMTS family (ADAMTS-1, -8, -9, -15 and –16) have also been implicated in embryonic development and angiogenesis.5

The kit provides enough reagents to perform 100 assays in a 96-well format.
The kit contains: • Aggrecanase-1 FRET substrate • 5-FAM reference standard for calibration • Assay buffer • Aggrecanase inhibitor • Stop Solution.

References:
1. Gur, PK. et al. J. Clin. Invest. 1059, 1335 (2000).
2. Tortorella, MD. Science 284, 1663 (1999).
3. Bonderson, J. Clin. Exp. Rheumatol. 26, 139 (2008).
4. Naito, S, et al. Pathol. Int. 57, 703 (2007).
5. Tang, BL. Int. J. Biochem. Cell Biol. 33, 33 (2001).

About AnaSpec
AnaSpec (anaspec.com) is a leading provider of integrated proteomics solutions to the world’s largest biotech, pharmaceutical, and academic research institutions. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents, and combinatorial chemistry.

 
 
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Written by / Agency / Source: AnaSpec, Inc.

 
 

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AnaSpec Introduces Industry’s First Fluorimetric Assay Kit for Aggrecanase-1 Activity Detection

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Publisher Contact: Ping Yang 
408-452-5055 ping[.]anaspec.com
 
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IMPORTANT INFORMATION: Issuance, publication or distribution of this press release in certain jurisdictions could be subject to restrictions. The recipient of this press release is responsible for using this press release and the information herein in accordance with the applicable rules and regulations in the particular jurisdiction. This press release does not constitute an offer or an offering to acquire or subscribe for any AnaSpec, Inc. securities in any jurisdiction including any other companies listed or named in this release.

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