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ChemImage and FDA Collaborate to Characterize Highly Unstable Polymorph of Pharmaceutical Compound - ChemImage, a world leader in Chemical Imaging technologies, is pleased to announce publication of the results of a collaborative study with the FDA to characterize the thermodynamics of a highly unstable polymorph of acetaminophen
ChemImage and FDA Collaborate to Characterize Highly Unstable Polymorph of Pharmaceutical Compound

 

NewswireToday - /newswire/ - Pittsburgh, PA, United States, 2008/11/11 - ChemImage, a world leader in Chemical Imaging technologies, is pleased to announce publication of the results of a collaborative study with the FDA to characterize the thermodynamics of a highly unstable polymorph of acetaminophen.

   
 
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The Journal of Pharmaceutical and Biomedical Analysis, a peer-reviewed journal, published "Raman detected differential scanning calorimetry of polymorphic transformations in acetaminophen" (doi: 10.1016/j.jpba.2008.09.008).

This publication outlines the application of a method for polymorph characterization which combines differential scanning calorimetry (DSC) and Raman microscopy. Interest in the polymorphic forms of acetaminophen comes as a result of the poor compression properties of the form used commercially in common pain relievers. An understanding of thermally driven polymorphic transformations is essential to the development and, ultimately, the use of another form that has improved compression properties with the same pharmacological effects.

“This is an important achievement as it opens the door to study other polymorphic transitions within the pharmaceutical arena,” stated David Tuschel, co-author and Principal Materials Scientist at ChemImage.

Through the simultaneous use of these individual methods, scientists from both organizations have worked to unambiguously identify polymorphic transitions, including the presence of a third form which is highly unstable and to date has not been isolated for powder X-ray diffraction.

This work comes as a product of the Cooperative Research and Development Agreement (CRADA) which ChemImage and the FDA signed in 2006, and was entered into for the design of protocols for validating Raman Chemical Imaging for applications in pharmaceutical research and process control.

About ChemImage
ChemImage Corporation (chemimage.com) is a world leader in Chemical Imaging technologies; provides instrumentation, software and expert consulting to government, industrial and academic organizations. ChemImage offers these products and services for a range of applications including defense, security, pharmaceuticals, forensics and biomedical diagnostic research. Our state-of-the-art Chemical Imaging technology can help to reveal critical chemical and biological information about processes, products and services.

ChemImage’s main headquarters is located in Pittsburgh, Pennsylvania and houses research and development laboratories as well as engineering and manufacturing facilities.

 
 
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Written by / Agency / Source: ChemImage Corporation

 
 

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ChemImage and FDA Collaborate to Characterize Highly Unstable Polymorph of Pharmaceutical Compound

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Publisher Contact: Linda Batykefer - ChemImage.com 
412-241-7335 x269 batykefer[.]chemimage.com
 
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