NewswireToday - /newswire/ -
Arlington, VA, United States, 2008/03/21 - Trevigen launches Cultrex® 24 Well Cell Invasion Assay kits to study invasive properties of cells. The kits accelerate screening of compounds that influence cellular invasion through extracellular matrices.
Trevigen’s Cultrex® Cell Invasion Assays were created in an effort to accelerate the screening process for compounds that influence cellular invasion through extracellular matrices. This process is fundamental to angiogenesis, embryonic development, immune responses, tumor cell metastasis, and cancer research.
To provide a platform for the analysis of responses to chemokines, toxins, drugs and other analytes of interest, for larger numbers of cells per well, Trevigen launched its Cultrex® 24 Well BME Cell Invasion Assay Kit. The modular format of the Cultrex® 24 Well BME Cell Invasion Assay offers flexible utility, and sufficient insert size for informative results. Trevigen also offers a Cultrex® 96 Well BME Cell Invasion Assay for those with higher throughput needs.
The Cultrex® BME Cell Invasion Assays utilize a simplified Boyden chamber design with an 8 µm polycarbonate (PC) membrane. Detection of cell migration is quantified using Calcein AM. Calcein AM is internalized by the cells, and intracellular esterases cleave the acetomethylester (AM) moiety. Free Calcein fluoresces brightly, and this fluorescence may be used to quantitate the number of cells that have migrated using a standard curve. For more information, contact Trevigen by phone, email or visit the website.
1. Tamilarasan KP, Kolluru GK, Rajaram M, Indhumathy M, Saranya R, Chatterjee S. 2006. Thalidomide attenuates nitric oxide mediated angiogenesis by blocking migration of endothelial cells. BMC Cell Biol. 7:17.
2. Borghesani PR, Peyrin JM, Klein R, Rubin J, Carter AR, Schwartz PM, Luster A, Corfas G, Segal RA. 2002. BDNF stimulates migration of cerebellar granule cells. Development 129:1435-1442.
Trevigen is a long standing provider of quality kits and reagents for researchers investigating programmed cell death, DNA damage and repair, cell differentiation and angiogenesis. Trevigen recently launched Cell Invasion Assays as part of it Cultrex® product line.