Peptide toxins are potent and selective compounds that can act on ion channels in plasma membrane of excitable cells.1 These high specificity and affinity compounds, often with diverse and selective pharmacologies, are used as pharmacological probes to study and characterize various receptor proteins involved in ion-channel function.1 These toxin peptides generally consist of a relatively small number of structural frameworks that are particularly suited to addressing the crucial issues of potency and stability.1 Multiple disulfide bonds constitute essential structural elements in many of these bio-active peptides, which are generated by proteolytic processing of pre-folded protein precursors and then released from the cells in the bio-active form into the extracellular medium to exert their physiological function.
Ca2+ Channel Blockers
Imperatoxin A (IpTxa)
Ryanodine receptor agonist
K+ Channel Blockers
Mast Cell Degranulating Peptide, MCD
Other Ion Channel Blockers
About AnaSpec, Inc.
AnaSpec, Inc. is a leading provider of integrated proteomics solutions to pharmaceutical, biotech, and academic research institutions throughout the world. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents (dyes, assay kits, & antibodies), and combinatorial chemistry.
1. Lewis, RJ. and ML. Garcia, Nat. Rev. Drug Discov. 2, 790 (2003)