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Pfizer Writes Off of $2.8bn Exubera Hits Inhalable Insulin Market Says Report - Report Buyer, the online destination for business intelligence for major industry sectors, has now added a new report showing that Pfizer has abandoned inhaled insulin product Exubera, resulting in a $2.8 billion write-off
Pfizer Writes Off of $2.8bn Exubera Hits Inhalable Insulin Market Says Report

 

NewswireToday - /newswire/ - London, United Kingdom, 2007/10/31 - Report Buyer, the online destination for business intelligence for major industry sectors, has now added a new report showing that Pfizer has abandoned inhaled insulin product Exubera, resulting in a $2.8 billion write-off.

   
 
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“Pipeline Insight: Insulins - Inhalable insulins unlikely to become blockbusters?” reports that overall
quarterly revenue for Pfizer fell 2.4 percent to $12 billion, and third-quarter net income dropped 77%. Pfizer also stands to lose patent protection within the next four years on drugs accounting for about half of its 2006 revenue. Key among these products is cholesterol drug Atorvastatin® (Lipitor), the world’s single most successful drug. The discontinuation of Exubera leaves Pfizer with one less drug to make up for those losses. While Pfizer will live to fight another day, the same cannot now be said for Exubera.

Obviously expecting big (and profitable) things, Pfizer paid $1.3 billion to Paris-based Sanofi-Aventis in 2006 for the rights to Exubera and insulin production plants in Germany. The product had only $4 million in worldwide sales in the second quarter, a disappointing result, the company said. Pfizer began airing television advertisements in recent months in an unsuccessful last-ditch attempt to stimulate demand and establish a foothold in the market.

Once touted as the next big thing in the treatment of diabetes, Exubera was forecast to be a blockbuster by most analysts. However, after separating the hype from the reality, authors of the report quickly recognised that a number of issues plagued the inhaled insulin class and thus restricted its commercial potential.

The proposed convenience advantage, and any concomitant benefit in compliance, of Exubera was negated by the fact that it was only available with a cumbersome and unwieldy delivery device. Furthermore, despite extensive clinical trials, the risks of long-term lung damage and carcinogenicity remained unquantified. New classes of antidiabetic agents, namely GLP-1 agonists (Byetta) and DPP4 inhibitors (Januvia) are also vying for market share, significantly restricting the size of the portion of market that would be available to Exubera.

Finally, the fact that Exubera was in essence a repackaged form of insulin, only offering a suggested convenience advantage rather than being a truly novel treatment made it unappealing to healthcare providers, who viewed the unmet need for inhaled insulin as non-existent and thus either refused to recommend it (UK and Germany) or offered reimbursement at a higher tier than most injected insulin (US).

The withdrawal of Exubera will force the developers of second generation inhaled insulins –namely Novo Nordisk, Eli Lilly and Mannkind – to assess whether the continuation of their projects is a viable decision. It has now become clear that true convenience in the form of a discreet portable device is required in order to win over patients, and a true therapeutic advantage compared to traditionally administered insulin needs to be proven to secure reimbursement.

“Pipeline Insight: Insulins - Inhalable insulins unlikely to become blockbusters?” is available from Report Buyer. For more information visit the website.

Report Buyer product ID: DAT04261

About Report Buyer
Report Buyer is a UK-based independent online store supplying business information on major industry sectors. These include the Automotive Industry, Banking & Finance, Energy & Utilities, Food & Drink, Telecoms and Pharma & Healthcare. The website now carries over 40,000 business information products, including market reports, studies and books. Report Buyer is the intelligent way to buy market research making it an essential resource for executives and information buyers worldwide. Subscribers receive a free monthly newsletter and email alerts on new titles in their areas of interest. A regularly updated blog provides information on the latest market trends.

 
 
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Pfizer Writes Off of $2.8bn Exubera Hits Inhalable Insulin Market Says Report

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