NewswireToday - /newswire/ -
Shirley, NY, United States, 2015/09/10 - In order to increase the efficacy of current therapeutic antibodies, Creative Biolavs, an industry leader in the field of antibody engineering field, has developed CeativeAbTM antibodies - Creative-Biolabs.com.
Bi-specific antibodies (BsAbs) are bioengineered antibodies that contain two different binding sites within a single molecule, which can specifically bind two different types of antigens. The most widely used application of bi-specific antibody is in cancer immunotherapy, which creates a therapeutic treatment approach for diseases with specific medical needs.
Compared with traditional antibodies, bi-specific antibodies have many advantages. The two arms can bring an antigen-expressing cell in close proximity to a killing cell, thus destroy the tumor cell. By binding to two different epitopes on an antigen, these two binding sites can significantly increase affinity or internalization rates of particular antigens on a cell's surface. They usually have a higher cytotoxic potential to bind to antigens with low expression level. Binding tumor cells utilizing a bi-specific antibody-drug conjugate (ADC) also holds great promise for the future development of therapeutics in various diseases.
With the development of antibody engineering, many types of bi-specific antibodies have been designed to enable short half-life, immunogenicity and side-effects caused by cytokine liberation. They include tri-functional antibodies, chemically linked Fabs and various types of bivalent and trivalent single-chain variable fragments (scFvs) and fusion proteins mimicking the variable domains of two antibodies. The furthest developed of these newer formats are the bi-specific T-cell engagers (BiTEs) and mAb2's, antibodies engineered to contain an Fcab antigen-binding fragment instead of the Fc constant region.
Creative Biolabs offers various types of bi-specific antibodies, including tri-functional antibodies and chemically linked Fabs, bivalent and bi-specific scFvs (tandem scFv, diabodies), bi-specific T-cell engagers (BiTEs) and scFv-Fab fusion proteins.
Based on various antibody formats such as IgGs, Fabs and scFvs, our Creative Discovery Platform™ provides a series of bi-specific antibodies to satisfy various customers' needs. We provide construction (expression & purification) as well as recombinant antibody production at scales£ ranging from hundreds of micrograms to grams level.
About Creative Biolabs
Creative Biolabs (creative-biolabs.com) is specialized in providing custom biotechnology and pharmaceutical services that cover the full scope of biotechnology needs of early drug discovery and drug development. As a trusted provider of the most cost-effective outsourcing solutions, Creative Biolabs has been working for a large number of satisfied clients from biotechnology and pharmaceutical companies as well as government and academic research laboratories all over the world. learn more about Creative Biolabs.