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Otava Ltd Introduces Calcium Channel Blockers Library - The Calcium Channel Blocker library was designed as a special screening collection comprising compounds with predicted calcium channels blocking activity and selectivity - OtavaChemicals.com
Otava Ltd Introduces Calcium Channel Blockers Library

 

NewswireToday - /newswire/ - Toronto, Ontario, Canada, 2015/03/11 - The Calcium Channel Blocker library was designed as a special screening collection comprising compounds with predicted calcium channels blocking activity and selectivity - OtavaChemicals.com.

   
 
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Nowadays, calcium channel blockers, or calcium antagonists, are widely used for treatment of a variety of conditions such as high blood pressure, migraines and Raynaud’s disease. OTAVA offers new Calcium Channel Blocker library containing 1262 compounds for antihypertensive research and drug discovery projects.

The calcium channels play a key role in the normal functioning of neuronal, neurosecretory and muscle cells and also these channels were identified at low levels in many cells not traditionally considered excitable, such as cells of the immune system.

Pathological changes in calcium channel expression have been shown to occur in several disease states including neuropathic pain, epilepsy and congestive heart failure. A number of human channelopaties that have been identified, for example in familial hemiplegic migraine and several cerebellar ataxias, are associated with dysfunction of calcium channels. Therefore, calcium channels are considered as promising drug targets.

The Calcium Channel Blocker library was designed as a special screening collection comprising compounds with predicted calcium channels blocking activity and selectivity. The compounds have been selected by pharmacophore screening of OTAVA Drug-like Green Collection using four ligand-based pharmacophore models, which were created based on the chemical structures of known calcium channel blockers.

 
 
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Written by / Agency / Source: Otava Ltd

 
 

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Otava Ltd Introduces Calcium Channel Blockers Library

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Publisher Contact: Andriy Petrenko - OtavaChemicals.com 
416-549-8030 info[.]otavachemicals.com
 
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IMPORTANT INFORMATION: Issuance, publication or distribution of this press release in certain jurisdictions could be subject to restrictions. The recipient of this press release is responsible for using this press release and the information herein in accordance with the applicable rules and regulations in the particular jurisdiction. This press release does not constitute an offer or an offering to acquire or subscribe for any Otava Ltd securities in any jurisdiction including any other companies listed or named in this release.

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