In recent years, the number of protein‐based pharmaceuticals reaching the marketplace has increased exponentially. Bioengineered proteins a class that includes therapeutic antibodies, recombinant cytokines and fusion proteins represent the effort to create protein-based drugs that expand the therapeutic envelope bye mitigating the limitations inherent in most biologicals. Fusion proteins area group of engineered biologicals that are designed to generate a highly specific therapeutic effect at a well-defined physiological site.
The current generation of FDA-approved fusion proteins addresses indications in a range of conditions with a third targeting autoimmunity. The three dozen fusion protein product candidates winding their way through the development process represent a much wider spectrum of therapeutic indications and protein engineering technology approaches. The complexity of fusion proteins and the challenges related to their design, manufacture and packaging are fostering a multi-disciplinary approach among market participants that includes the incorporation of concurrent development principles to properly risk manage FP product programs. Cooperation between drug developers, packaging designers and delivery technologists is occurring much earlier in the drug development cycle, allowing product engineering to be tailored to the bioavailability targets and pharmacokinetic profiles of each specific drug therapy.
A comprehensive analysis of therapeutic fusion proteins is the subject of a new and comprehensive report. The report Therapeutic Fusion Proteins to 2018: Products, Pipelines, Players and Prospects - includes analysis of approved fusion proteins, assessments of pipeline drug candidates, evaluations of therapeutic markets, an examination of market factors, and profiles of market participants.
Greystone Research Associates (greystoneassociates.org) is a medical technology consulting firm focused on the areas of medical market strategy, product commercialization, venture development, and market research. We assist medical and healthcare market participants in achieving their business objectives through the creation of detailed development strategies, product commercialization programs, and comprehensive market and technology research and analysis. Our market research publications are designed, researched and written to provide timely and insightful information and data on focused market segments, with the aim of providing market participants with the essential knowledge to refine and execute their marketing plans and financial targets.