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Written by / Agency / Source: AnaSpec, Inc.

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AnaSpec Launches the EnzoLyte™ 520 Renin Assay Kit with Ultra-high Sensitivity - The past decade has witnessed the development of a number of synthetic renin inhibitors1-3
AnaSpec Launches the EnzoLyte™ 520 Renin Assay Kit with Ultra-high Sensitivity

 

NewswireToday - /newswire/ - San Jose, CA, United States, 2007/01/08 - The past decade has witnessed the development of a number of synthetic renin inhibitors1-3.

   
 
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However, increasing demand for accelerated drug discovery and automated inhibitor screening has generated a need for a continuous, homogeneous assay with even greater sensitivity. With the introduction of the ultra-sensitve EnzoLyte™ 520 Renin Assay Kit, AnaSpec now offers a renin assay kit that is 40x more sensitive than comparable kits currently in the market.

Renin, a highly specific aspartyl protease, cleaves angiotensinogen, to yield angiotensin I, which is further converted into angiotensin II by ACE (Angiotensin Converting Enzyme). Angiotensin II constricts blood vessels, leading to increased blood pressure. Angiotensin II also increases the secretion of ADH and aldosterone, and stimulates the hypothalamus to activate the thirst reflex. Since an overactive renin-angiotensin system leads to hypertension, renin is an attractive target for the treatment of this disease.

While existing renin assay kits offer sub-nanomolar potency and selectivity, AnaSpec’s EnzoLyte™ 520 Renin Assay Kit offers picomolar sensitivity – the highest sensitivity available for commercial renin assay kits.

AnaSpec also offers a shorter emission wavelength kit, EnzoLyte™ 390 Renin Assay Kit -a cost-effective option that offers greater sensitivity than EDANS/DABCYL-based renin assay kits.

EnzoLyte™ 520 Renin Assay Kit
EnzoLyte™ 390 Renin Assay Kit

EnzoLyte™ 520 Renin Assay Kit
FRET pair: 5-FAM/QXLTM520
Ex/Em (nm): 490/520
Min. Detectable Renin Conc. (pM): 2.5
Interference from Autofluorescence: Minimal
Sensitivity: Ultra-sensitive

EnzoLyte™ 390Renin Assay Kit
FRET pair: Mc-Ala/Dnp
Ex/Em (nm): 330/390
Min. Detectable Renin Conc. (pM): 25
Interference from Autofluorescence: High
Sensitivity: Good

Company B
FRET pair: EDANS/DABCYL
Ex/Em (nm): 335/495
Min. Detectable Renin Conc. (pM):100
Interference from Autofluorescence:High
Sensitivity: Minimal

For more information, visit our website.

AnaSpec, Inc., located in San Jose, CA, is a leading provider of integrated proteomics solutions to pharmaceutical, biotech, and academic research institutions throughout the world. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents, and combinatorial chemistry.

 
 
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Written by / Agency / Source: AnaSpec, Inc.

 
 

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AnaSpec Launches the EnzoLyte™ 520 Renin Assay Kit with Ultra-high Sensitivity

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Publisher Contact: Debra Thai 
408 452-5055 marketing[.]anaspec.com
 
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