Tumor necrosis factor (TNF) inhibitors are currently the only therapeutic class available to psoriatic arthritis (PsA) patients in need of additional therapy beyond standard of care. This represents a significant unmet need for alternative therapies for TNF inhibitor refractory patients.
New analysis from Frost & Sullivan’s (healthcare.frost.com) United States Market for Psoriatic Arthritis Pharmacotherapy research finds that psoriatic arthritis pharmacotherapeutics prescribed as add-on therapies to standard background therapy earned revenues of approximately $751.5 million in 2011. Frost & Sullivan estimates this to reach $1.3 billion in 2017.
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TNF inhibitors, a well-established drug class, have laid the groundwork for the next-generation of effective disease modifying antirheumatic drugs and biologics with improved safety and efficacy profiles. The development of novel therapies for this complex disease, however, is hindered by several factors, such as an incompletely understood pathogenesis and a perception that PsA is a milder disease than rheumatoid arthritis. In addition, dermatologists may be less inclined than rheumatologists to prescribe biologics, hindering acceptance of these valuable treatments within the physician community.
Consequently, TNF inhibitors are likely to continue as the first line of treatment for PsA, initially limiting the uptake of new agents to second line use.
"While some TNF inhibitors that are effective in rheumatoid arthritis are also effective in PsA, patients with moderate to severe forms of the disease may not always respond to them," said Frost & Sullivan Senior Industry Analyst Debbie Toscano. "This creates a strong need for alternative therapies."
To improve their therapies' commercial acceptance, pharmaceutical companies need to raise the level of disease awareness and alter the perception of the potential severity of PsA. In addition, robust data supporting the clinical benefits of new agents in comparison with TNF inhibitors can help to overcome the entrenchment of this class and win over payers, prescribers and patients.
"With the impending launch of three new therapies for the treatment of PsA in 2014, the awareness of PsA is expected to increase substantially," noted Toscano. "This will renew interest in PsA, as patients and physicians will finally be presented with alternative treatments."
United States Market for Psoriatic Arthritis Pharmacotherapy is part of the Life Sciences Growth Partnership Services program, which also includes research in the following markets: United States Market for Rheumatoid Arthritis Pharmacotherapy, United States Rheumatic Diseases Therapeutics Market, United States Market for Ankylosing Spondylitis Pharmacotherapy, and U.S. Rheumatoid Arthritis Market: Assessment of Biologics and New Treatments. All research services included in subscriptions provide detailed market opportunities and industry trends evaluated following extensive interviews with market participants.
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United States Market for Psoriatic Arthritis Pharmacotherapy / NB3A-52