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Fremont, CA, United States, 2012/01/25 - AnaSpec, EGT Group is pleased to announce the release of an ultrasensitive ELISA assay for quantitatingα-synuclein.
The SensoLyte® α-Synuclein Quantitative ELISA Kit (Human/Mouse/Rat) provides a convenient and quantitative assay for determining α-Synuclein amount in cell and tissue lysate as well as in body fluids. Compared to other anti-α-Synuclein ELISA kits on the market, this one-step, mix-and-read assay takes less time to run. HRP conjugated detection antibody is added simultaneously with the samples and standards during the assay, eliminating extra incubation and washing steps.
α-Synuclein is a major component of Lewy bodies found in affected neurons of patients with Parkinson’s disease.1-4 This protein has a mass of 14.5 kDa (140 amino acids long) and consists of a conserved degenerative amino-terminal domain and an acidic carboxyl-terminal that has a higher sequence divergence.1-4 α-Synuclein is predominantly expressed in brain, specifically in cerebellum, thalamus, neocortex, hippocampus, and striatum regions.1-2 Other tissues also express α-Synuclein but at very low levels.1-4 The physiological role of α-Synuclein is not well understood. However, the presence of imperfect KTKEGV lipid interacting repeats suggests that it may be involved in synaptic vesicle homeostasis.3
1. Rivers, R. et al. Protein Science 17, 887 (2008).
2. Bruening, W. et al. Cancer. 88, 2154 (2000).
3. George M. J. Genome Biology3, 1 (2001).
4. Latawiec, D. et al. PloS ONE 5, 1 (2010).
AnaSpec, EGT Group
AnaSpec, Eurogentec Group (anaspec.com / eurogentec.com) is a leading provider of integrated proteomics and genomics solutionsTM for worldwide life science research. AnaSpec offers expertise in peptides, detection reagents, antibodies, assay kits, amino acids, oligonucleotides, and qPCRs. AnaSpec carries a broad product line of biochemicals and reagents for basic research, high-throughput screening and drug discovery. AnaSpec also provides premier custom services including peptide synthesis, antibody production, assay development, fluorescent dyes, and oligonucleotide synthesis. AnaSpec is certified to ISO 9001:2008.